Current and potential therapeutic uses of growth hormone and insulin-like growth factor I.

The accepted and potential uses of GH and IGF-I are summarized in Table 1. In general, the research on the therapeutic uses of IGF-I is at a much earlier state of development compared with GH The use of GH in the treatment of children with GH deficiency is well accepted, and its use in the treatment of short stature of renal failure also is widely accepted. The FDA has approved the use of GH in children with short stature caused by GH insufficiency and renal failure. The use of GH in patients with Turner syndrome has not been approved by the FDA, although it has been approved in several other countries. The use of GH for the treatment of adults with GH deficiency is approved in several countries but it is not approved in the Unites States. With the exception of the cases with GHIS, the use of IGF-I as a therapeutic agent cannot yet be regarded as of proven usefulness. The potential uses of GH and IGF-I are an area of active investigation and will continue to enlighten our understanding of human disease and disorders of growth.