Singh V K, Takemoto J Y
Immunology Laboratory, MSRB-I, University of Michigan, Ann Arbor 48109-0656, USA.
FEMS Immunol Med Microbiol. 1996 Sep;15(2-3):177-9. doi: 10.1111/j.1574-695X.1996.tb00069.x.
Syringomycin E (SR-E) is a low molecular weight bacterial lipodepsipeptide with antifungal properties. Owing to immunosuppressive activities of such compounds as cyclosporine, FK506 and rapamycin, we studied the effect of SR-E on proliferation of human blood lymphocytes in vitro. SR-E, by itself, had no effect but the mitogen-induced lymphocyte proliferation was significantly suppressed. The suppressive effect was more pronounced with pokeweed mitogen (PWM) as compared to phytohemagglutinin (PHA) or monoclonal antibody to CD3 (anti-CD3). Since these mitogens induce cellular immunity (T cell-dependent), SR-E may potentially be a novel immunosuppressive compound.
丁香霉素E（SR-E）是一种具有抗真菌特性的低分子量细菌脂肽。鉴于环孢素、FK506和雷帕霉素等化合物具有免疫抑制活性，我们研究了SR-E对人外周血淋巴细胞体外增殖的影响。单独使用SR-E时无作用，但丝裂原诱导的淋巴细胞增殖受到显著抑制。与植物血凝素（PHA）或抗CD3单克隆抗体相比，美洲商陆丝裂原（PWM）诱导的抑制作用更为明显。由于这些丝裂原诱导细胞免疫（T细胞依赖性），SR-E可能是一种新型免疫抑制化合物。
