Norregaard J C, Gerner N, Jensen O A, Prause J U
Department of Ophthalmology, Hvidovre University Hospital, Denmark.
Graefes Arch Clin Exp Ophthalmol. 1996 Sep;234(9):569-72. doi: 10.1007/BF00448801.
To describe patient characteristics, risk of recurrence, and survival in patients with premalignant and malignant melanocytic lesions of the conjunctiva.
In a retrospective study, 55 cases with a minimum follow-up of 10 years were reviewed.
The actuarial 5-and 10-year survival rates were 86% (95% Cl: 76-96%) and 73% (95% Cl: 60-87%) respectively. The 5-year risk of local recurrence was 35% (95% Cl: 21-49%), and the 10-year risk was 43% (95% Cl: 28-58%). Primary acquired melanosis with atypia was the first manifestation in 13 cases, malignant melanoma in 42 cases. No significant difference in survival and recurrence was found between the two groups or by gender, location of primary lesion, histological characteristics, or extent of surgical procedure. A minimum incidence of 0.052 cases a year per 100 000 in Denmark was calculated.
The results are estimated to represent a nationwide sample of patients. No prognostic factors of significance were identified.
描述结膜恶性黑色素瘤前期病变和恶性病变患者的特征、复发风险及生存率。
在一项回顾性研究中，对55例至少随访10年的病例进行了分析。
5年和10年的精算生存率分别为86%（95%可信区间：76 - 96%）和73%（95%可信区间：60 - 87%）。5年局部复发风险为35%（95%可信区间：21 - 49%），10年风险为43%（95%可信区间：28 - 58%）。13例患者首发表现为非典型原发性获得性黑色素沉着，42例为恶性黑色素瘤。两组之间或按性别、原发灶位置、组织学特征或手术范围分析，生存率和复发率均无显著差异。丹麦每年每10万人中结膜黑色素瘤的最低发病率为0.052例。
研究结果估计代表了全国范围内的患者样本。未发现有显著意义的预后因素。
