Giusti V, Schneiter P, Thiébaud D, Landry M, Burckhardt P, Jéquier E, Tappy L
Department of Internal Medicine, Lausanne University Hospital, Switzerland.
Int J Obes Relat Metab Disord. 1996 Sep;20(9):842-7.
To determine the influence of body weight, fat mass, and fat distribution on resting endogenous glucose production in healthy lean and overweight individuals.
measurements were performed in the resting postabsorptive state in individuals receiving an unrestricted diet.
Institute of Physiology of Lausanne University.
resting post absorptive glucose production, glycogenolysis and gluconeogenesis; resting energy expenditure and net substrate oxidation.
Endogenous glucose production was positively correlated with body weight, lean body mass, energy expenditure and carbohydrate oxidation. Gluconeogenesis was positively correlated with net lipid oxidation and energy expenditure, and negatively correlated with net carbohydrate oxidation. No correlation with body fat or fat distribution was observed.
Gluconeogenesis shows a large interindividual variability. Net lipid oxidation and not body fat appears to be a major determinant of gluconeogenesis.
确定体重、脂肪量和脂肪分布对健康瘦人和超重个体静息内源性葡萄糖生成的影响。
在接受无限制饮食的个体的静息吸收后状态下进行测量。
洛桑大学生理研究所。
静息吸收后葡萄糖生成、糖原分解和糖异生；静息能量消耗和净底物氧化。
内源性葡萄糖生成与体重、瘦体重、能量消耗和碳水化合物氧化呈正相关。糖异生与净脂质氧化和能量消耗呈正相关，与净碳水化合物氧化呈负相关。未观察到与体脂或脂肪分布的相关性。
糖异生存在较大的个体间差异。净脂质氧化而非体脂似乎是糖异生的主要决定因素。
