Rotola A, Costa S, Di Luca D, Stefanon B, Villani C, Micheletti L, Montemagno U, Bolis P F, Cassai E
Institute of Microbiology, University of Ferrara, Italy.
Intervirology. 1995;38(6):325-31. doi: 10.1159/000150459.
Forty-nine women with cervical intraepithelial neoplasia (CIN) grade II were treated with systemic and/or local beta-interferon (beta-IFN) applications. The aim of the study was to compare the efficacy of different routes for the administration of beta-IFN, evaluate local and systemic beta-IFN tolerance, and determine whether disappearance of neoplastic lesions was related to the resolution of the concomitant human papillomavirus infection. The patients were randomized to receive intramuscular, intralesional or a combination of intramuscular and intralesional administration, or conventional treatment. Significant differences in the rate of lesion regression were observed between treated and untreated women. The highest frequency of complete response was observed with the therapy combining intramuscular and intralesional treatment.
49名患有宫颈上皮内瘤变（CIN）II级的女性接受了全身和/或局部β-干扰素（β-IFN）治疗。本研究的目的是比较β-IFN不同给药途径的疗效，评估局部和全身对β-IFN的耐受性，并确定肿瘤性病变的消失是否与同时存在的人乳头瘤病毒感染的消退有关。患者被随机分为接受肌肉注射、瘤内注射或肌肉注射与瘤内注射联合治疗，或接受传统治疗。在接受治疗和未接受治疗的女性之间观察到病变消退率存在显著差异。肌肉注射与瘤内注射联合治疗的完全缓解频率最高。
