Schneider A, Grubert T, Kirchmayr R, Wagner D, Papendick U, Schlunck G
Department of Obstetrics and Gynecology, University of Ulm, Germany.
Arch Gynecol Obstet. 1995;256(2):75-83. doi: 10.1007/BF00634712.
Dose dependent response of cervical intraepithelial neoplasia (CIN) to topically administered interferon (IFN) gamma was assessed and compared with conventional laser therapy.
33 women were included in a randomized phase II trial which was double blinded for IFN dosages. Twenty-four patients received IFN gamma-1 beta gel and a control group of nine patients was treated with laser surgery. 18 patients had smears suggesting CIN II and 15 patients had smears suggesting CIN III. The response was assessed 6 months after starting of IFN gamma-1 beta treatment or having laser surgery.
Topical IFN gamma-1 beta treatment gave a cure rate of 42% independent of IFN dosage as compared to an 89% cure rate with laser therapy (P = 0.02). Patients with CIN II responded better compared with patients with CIN III. Current smokers showed a significantly lower cure rate whereas use of oral contraceptives (OC) did not influence response. High viral load with high risk types of human papillomaviruses (HPV) was associated with a better response.
评估宫颈上皮内瘤变（CIN）对局部应用干扰素（IFN）γ的剂量依赖性反应，并与传统激光治疗进行比较。
33名女性纳入一项随机II期试验，该试验对IFN剂量进行双盲。24名患者接受IFNγ-1β凝胶治疗，9名患者的对照组接受激光手术治疗。18名患者涂片提示CIN II，15名患者涂片提示CIN III。在开始IFNγ-1β治疗或进行激光手术后6个月评估反应。
局部应用IFNγ-1β治疗的治愈率为42%，与IFN剂量无关，而激光治疗的治愈率为89%（P = 0.02）。CIN II患者的反应比CIN III患者更好。当前吸烟者的治愈率显著较低，而口服避孕药（OC）的使用不影响反应。高危型人乳头瘤病毒（HPV）高病毒载量与更好的反应相关。
