Mitzner E, Groth T
Technische Fachhochschule Wildau-WIP-Gruppen Adlershof, Berlin, Germany.
J Biomater Sci Polym Ed. 1996;7(12):1105-18. doi: 10.1163/156856296x00598.
Non-polar hydrophobic poly(isobutylene)glycol (PIBG) was substituted for poly(tetramethylene ether)glycol (PTMEG) in poly(ether urethanes) based on 4,4'-methylenebis-(phenylisocyanate) (MDI) and 1,4-butanediol (BD) as chain extender. Two series of polyurethanes differing in their soft segment length, polymer composition, and hard segment content were studied by dynamic mechanical analysis (DMA) and static, as well as dynamic, contact angle measurements. The thrombogenicity of these polymers was characterized by studying the adhesion and activation of platelets using ELISA for GMP 140 and fluorescence microscopy. It was found by DMA that in PIBG-containing polyurethanes (PUE) exist soft domains containing hard segments, strictly separated hard segment domains, and hard segments partially mixed with soft segments. Contact angle measurements revealed that 25% PIBG or even less, are sufficient for a remarkable enrichment of these non-polar soft segments on the polymer surface. The platelet adhesion/activation on these materials was demonstrated to increase with the rise in hard segment content, as well as with an enhancement of the PIBG content. However, comparison of PIBG-containing PUE with medical applied polypropylene and pellethane expressed that PUE with PIBG content equal or less 25% have excellent haemocompatibility.
在基于4,4'-亚甲基双（苯基异氰酸酯）（MDI）和1,4-丁二醇（BD）作为扩链剂的聚（醚聚氨酯）中，用非极性疏水聚（异丁烯）二醇（PIBG）替代聚（四亚甲基醚）二醇（PTMEG）。通过动态力学分析（DMA）以及静态和动态接触角测量，研究了两个系列在软段长度、聚合物组成和硬段含量方面存在差异的聚氨酯。通过使用ELISA检测GMP 140和荧光显微镜研究血小板的粘附和活化，来表征这些聚合物的血栓形成性。通过DMA发现，在含PIBG的聚氨酯（PUE）中存在包含硬段的软域、严格分离的硬段域以及与软段部分混合的硬段。接触角测量表明，25%的PIBG甚至更少，就足以使这些非极性软段在聚合物表面显著富集。这些材料上的血小板粘附/活化被证明随着硬段含量的增加以及PIBG含量的提高而增加。然而，将含PIBG的PUE与医用聚丙烯和聚醚氨酯进行比较表明，PIBG含量等于或小于25%的PUE具有优异的血液相容性。
