内源性干扰素在丙型肝炎病毒（HCV）感染以及人类免疫缺陷病毒（HIV）与HCV合并感染中的作用。

Role of endogenous interferon in hepatitis C virus (HCV) infection and in coinfection by HIV and HCV.

作者信息

Cribier B, Schmitt C, Rey D, Lang J M, Kirn A, Stoll-Keller F

机构信息

Institut de Virologie/INSERM U74, Strasbourg, France.

出版信息

Res Virol. 1996 Sep-Oct;147(5):263-6. doi: 10.1016/0923-2516(96)82284-9.

DOI:10.1016/0923-2516(96)82284-9

PMID:8880995

Abstract

Recombinant interferon alpha (IFN alpha), widely used in the treatment of chronic hepatitis C, can induce a major decrease in HCV viraemia in good responders. In order to evaluate the possible role of endogenous IFN, using a biological method, we measured the IFN levels in 74 patients infected by HCV and in 73 patients coinfected by HIV and HCV. IFN levels were much higher in the HCV+HIV+ group and were linked to HIV viraemia. In those patients with high IFN levels, the HCV viraemia was lower, but only in the HCV+ group. These data suggest that IFN can partly control the HCV viraemia, but in coinfection by HIV, the response of HCV to endogenous IFN could be lower.

摘要

重组干扰素α（IFNα）广泛用于治疗慢性丙型肝炎，在治疗反应良好的患者中可使丙型肝炎病毒血症大幅下降。为了评估内源性干扰素的可能作用，我们采用生物学方法测量了74例丙型肝炎病毒感染者和73例同时感染人类免疫缺陷病毒（HIV）和丙型肝炎病毒患者的干扰素水平。在HCV+HIV+组中，干扰素水平要高得多，且与HIV病毒血症相关。在那些干扰素水平高的患者中，丙型肝炎病毒血症较低，但仅在HCV+组中如此。这些数据表明，干扰素可以部分控制丙型肝炎病毒血症，但在合并感染HIV时，丙型肝炎病毒对内源性干扰素的反应可能较低。