γ-3重链病1例新病例。生化与免疫学检查。

A new case of gamma-3 heavy chain disease. Biochemical and immunological investigations.

作者信息

Biewenga J, van Loghem E

出版信息

Vox Sang. 1979;36(4):193-8. doi: 10.1111/j.1423-0410.1979.tb04423.x.

DOI:10.1111/j.1423-0410.1979.tb04423.x

Abstract

A new gamma 3 heavy chain disease (gamma 3-HCD) protein (Emm) is described. A molecular weight of 70,000-80,000 daltons was estimated. Antigenic analysis showed that protein Emm lacks light chains and the CH1 domain of heavy chains, whereas the antigenic determinants of the gamma 3 Fc fragment (CH2 and CH3 domains) as well as those of the gamma 3 hinge region were present. Since the anomalous protein was temporarily present in serum Emm, a transient triggering of a cell clone which produces the gamma 3-HCD protein is suggested.

摘要

描述了一种新的γ3重链病（γ3-HCD）蛋白（Emm）。估计其分子量为70,000 - 80,000道尔顿。抗原分析表明，Emm蛋白缺乏轻链和重链的CH1结构域，而γ3 Fc片段（CH2和CH3结构域）以及γ3铰链区的抗原决定簇则存在。由于这种异常蛋白暂时存在于血清Emm中，提示产生γ3-HCD蛋白的细胞克隆有短暂触发。