基于病理结果的胃癌手术治疗及辅助化疗

Surgical treatment and adjuvant chemotherapy of gastric cancer on the basis of pathological findings.

作者信息

Yoshida K, Ikeuchi H, Oshibe M, Machida T, Hoshi H, Takahashi M

出版信息

Tohoku J Exp Med. 1977 Jun;122(2):113-20. doi: 10.1620/tjem.122.113.

DOI:10.1620/tjem.122.113

Abstract

Gastrectomy was performed in 626 outo 692 operated cases of gastric cancer. Histologic examination of the resected specimens revealed that the cancer was confined to the mucosal (m) or submucosal layer (sm) in 256 cases, advanced to the muscularis propria (pm) or subserosal layer (ss) in 110, and to the serosa (se) or the surrounding organs (si, sei) in 260. 238 (93%) of m and sm cases were free from lymphnode metastasis. Lymphnode metastasis was noted in 51 (46%) of pm and ss cases, 177 (77%) were positive in lymphnode metastasis and 108 (47%) showed metastasis in n2 and n3 degree. Adjuvant chemotherapy fairly improved the psotoperative survival rate of the advanced cases with lymphnode metastasis, serosal involvement, or lymph and blood vessel involement of gastric cancer.

摘要

在692例接受手术的胃癌病例中，626例行胃切除术。对切除标本的组织学检查显示，256例癌症局限于黏膜（m）或黏膜下层（sm），110例进展至固有肌层（pm）或浆膜下层（ss），260例侵犯至浆膜（se）或周围器官（si、sei）。238例（93%）m和sm病例无淋巴结转移。在pm和ss病例中，51例（46%）有淋巴结转移，177例（77%）淋巴结转移呈阳性，108例（47%）显示为N2和N3级转移。辅助化疗显著提高了伴有淋巴结转移、浆膜受累或胃癌淋巴和血管受累的进展期病例的术后生存率。