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The role of recombinant human DNase in the treatment of patients with cystic fibrosis: many promises, more problems.重组人脱氧核糖核酸酶在囊性纤维化患者治疗中的作用：充满希望，但问题更多。
Thorax. 1996 Jul;51(7):750-5. doi: 10.1136/thx.51.7.750.
2
Recombinant human DNase in cystic fibrosis.重组人脱氧核糖核酸酶在囊性纤维化中的应用
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[Cystic fibrosis: current therapy. Inhalation therapy with recombinant DNAse].[囊性纤维化：当前的治疗方法。重组脱氧核糖核酸酶吸入疗法]
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DNase in cystic fibrosis: the challenge of assessing response and maximising benefit.囊性纤维化中的脱氧核糖核酸酶：评估反应及实现效益最大化面临的挑战
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Recombinant human DNase inhalation in normal subjects and patients with cystic fibrosis. A phase 1 study.
JAMA. 1992 Apr 8;267(14):1947-51.
7
Neutrophil proteinases and rhDNase therapy in cystic fibrosis.中性粒细胞蛋白酶与重组人脱氧核糖核酸酶治疗囊性纤维化
Eur Respir J. 1996 Nov;9(11):2193-5. doi: 10.1183/09031936.96.09112193.
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DNase trials in cystic fibrosis.
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Placebo-controlled n-of-1 trials in cystic fibrosis.囊性纤维化的安慰剂对照单病例试验。
Eur Respir J. 1999 Oct;14(4):993; author reply 994. doi: 10.1034/j.1399-3003.1999.14d44.x.

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Long-term effects of aerosolised rhDNase on pulmonary disease progression in patients with cystic fibrosis.雾化重组人脱氧核糖核酸酶对囊性纤维化患者肺部疾病进展的长期影响。
Thorax. 1998 Dec;53(12):1014-7. doi: 10.1136/thx.53.12.1014.

本文引用的文献

1
Liquefaction of viscous purulent exudates by deoxyribonuclease.脱氧核糖核酸酶对粘性脓性渗出物的液化作用。
Lancet. 1950 Dec 9;2(6641):739-42. doi: 10.1016/s0140-6736(50)91676-x.
2
STUDIES ON PULMONARY SECRETIONS. I. THE OVER-ALL CHEMICAL COMPOSITION OF PULMONARY SECRETIONS FROM PATIENTS WITH CYSTIC FIBROSIS, BRONCHIECTASIS, AND LARYNGECTOMY.肺分泌物研究。I. 囊性纤维化、支气管扩张症和喉切除患者肺分泌物的整体化学成分
Am Rev Respir Dis. 1963 Aug;88:199-204. doi: 10.1164/arrd.1963.88.2.199.
3
Aerosolized pancreatic dornase and antibiotics in pulmonary infections: use in patients with postoperative and nonoperative infections.雾化吸入胰脱氧核糖核酸酶和抗生素治疗肺部感染：在术后感染和非手术感染患者中的应用
JAMA. 1961 Dec 2;178:878-86. doi: 10.1001/jama.1961.03040480008003.
4
Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasis.胰腺囊性纤维化和支气管扩张时气管支气管分泌物的成分
Pediatrics. 1959 Nov;24:739-45.
5
In-vitro evaluation of effect of enzymes on tracheobronchial secretions from patients withcystic fibrosis.酶对囊性纤维化患者气管支气管分泌物影响的体外评估
Pediatrics. 1961 Apr;27:589-96.
6
Aerosols of pancreatic dornase in bronchopulmonary disease.支气管肺部疾病中胰脱氧核糖核酸酶气雾剂的应用
Ann Allergy. 1954 Jan-Feb;12(1):71-7.
7
Deoxyribonuclease in the treatment of purulent bronchitis.脱氧核糖核酸酶治疗化脓性支气管炎
Thorax. 1953 Dec;8(4):295-300. doi: 10.1136/thx.8.4.295.
8
DNase trials in cystic fibrosis.
Eur Respir J. 1995 Oct;8(10):1786-91. doi: 10.1183/09031936.95.08101786.
9
Effects of combined treatment with rhDNase and airflow oscillations on spinnability of cystic fibrosis sputum in vitro.重组人脱氧核糖核酸酶与气流振荡联合治疗对体外囊性纤维化痰液可纺性的影响。
Pediatr Pulmonol. 1995 Aug;20(2):78-82. doi: 10.1002/ppul.1950200205.
10
The relationship between infection and inflammation in the early stages of lung disease from cystic fibrosis.
Pediatr Pulmonol. 1995 Aug;20(2):63-70. doi: 10.1002/ppul.1950200203.

The role of recombinant human DNase in the treatment of patients with cystic fibrosis: many promises, more problems.

作者信息

Zach M S

机构信息

Paediatric Department, University of Graz, Austria.

出版信息

Thorax. 1996 Jul;51(7):750-5. doi: 10.1136/thx.51.7.750.

DOI:10.1136/thx.51.7.750
PMID:8882085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC472501/
Abstract
摘要