中性粒细胞蛋白酶与重组人脱氧核糖核酸酶治疗囊性纤维化 - Suppr

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超能文献

Neutrophil proteinases and rhDNase therapy in cystic fibrosis.

作者信息

Vogelmeier C, Döring G

出版信息

Eur Respir J. 1996 Nov;9(11):2193-5. doi: 10.1183/09031936.96.09112193.

DOI:10.1183/09031936.96.09112193

PMID:8947058

Abstract

摘要

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Neutrophil proteinases and rhDNase therapy in cystic fibrosis.中性粒细胞蛋白酶与重组人脱氧核糖核酸酶治疗囊性纤维化

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Proteinase 3, a potent secretagogue in airways, is present in cystic fibrosis sputum.蛋白酶3是气道中的一种强效促分泌素，存在于囊性纤维化患者的痰液中。

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Reduction in neutrophil elastase concentration by recombinant alphal-antitrypsin (recAAT) does not alter bacterial loading in the sputum of cystic fibrosis patients.重组α1-抗胰蛋白酶（recAAT）降低中性粒细胞弹性蛋白酶浓度并不会改变囊性纤维化患者痰液中的细菌载量。

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Influence of DNA on the activities and inhibition of neutrophil serine proteases in cystic fibrosis sputum.DNA 对囊性纤维化痰液中中性粒细胞丝氨酸蛋白酶的活性和抑制的影响。

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EPI-hNE4, a proteolysis-resistant inhibitor of human neutrophil elastase and potential anti-inflammatory drug for treating cystic fibrosis.EPI-hNE4，一种对人中性粒细胞弹性蛋白酶具有抗蛋白水解作用的抑制剂，也是用于治疗囊性纤维化的潜在抗炎药物。

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Neutrophil elastase enhances sputum solubilization in cystic fibrosis patients receiving DNase therapy.中性粒细胞弹性蛋白酶增强接受 DNase 治疗的囊性纤维化患者的痰液溶解。

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The protease-antiprotease battle in the cystic fibrosis lung.囊性纤维化肺部的蛋白酶-抗蛋白酶之战

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PLoS One. 2011;6(12):e28526. doi: 10.1371/journal.pone.0028526. Epub 2011 Dec 9.

The protease-antiprotease battle in the cystic fibrosis lung.囊性纤维化肺部的蛋白酶-抗蛋白酶之战

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