Smith A J, Power I
University Hospital of Wales, Heath Park, Cardiff.
Anaesthesia. 1996 Sep;51(9):883-5. doi: 10.1111/j.1365-2044.1996.tb12626.x.
A randomised, double-blind, controlled trial was undertaken to compare three different methods of reducing pain during the intravenous injection of propofol. In 101 patients undergoing daycase surgery, verbal rating scores for pain during injection of propofol were compared immediately after intravenous pretreatment with ketorolac 10 mg, lignocaine 10 mg or saline. Neither pain during injection (p = 0.129), nor venous sequelae at 7 days postoperatively were significantly different between the three treatments. Pain during propofol injection remains a confounding clinical problem.
