Parmar A K, Koay C K
Department of Anaesthesia and Surgical Intensive Care, New Changi Hospital, Singapore, Republic of Singapore.
Anaesthesia. 1998 Jan;53(1):79-83. doi: 10.1111/j.1365-2044.1998.00248.x.
Propofol is frequently associated with pain on injection. Previous studies have suggested that chilling of the propofol decreases pain significantly. This prospective, randomised, double-blind trial was designed to assess the effectiveness of cold propofol compared with propofol premixed with lignocaine in minimising pain on injection. Patients were allocated to one of four groups: propofol + lignocaine 0.1 mg.kg-1, propofol + lignocaine 0.2 mg.kg-1, cold propofol and a control group consisting of propofol premixed with normal saline and maintained at room temperature. The results of this study show that cold propofol is associated with a very high incidence of injection pain while lignocaine 0.1 mg.kg-1 premixed with propofol significantly decreases the incidence of pain (p < 0.001). Increasing the dosage of lignocaine above 0.1 mg.kg-1, however, does not significantly decrease the incidence of pain further. The addition of lignocaine also significantly decreases the incidence of excitatory side-effects.
丙泊酚常常与注射时疼痛相关。既往研究提示，丙泊酚冷藏可显著减轻疼痛。本前瞻性、随机、双盲试验旨在评估冷藏丙泊酚与丙泊酚预混利多卡因相比在减轻注射疼痛方面的有效性。患者被分配至四组之一：丙泊酚+0.1mg.kg-1利多卡因、丙泊酚+0.2mg.kg-1利多卡因、冷藏丙泊酚以及由丙泊酚与生理盐水预混并维持在室温的对照组。本研究结果显示，冷藏丙泊酚与注射疼痛的高发生率相关，而0.1mg.kg-1利多卡因与丙泊酚预混可显著降低疼痛发生率（p<0.001）。然而，将利多卡因剂量增加至0.1mg.kg-1以上并不能进一步显著降低疼痛发生率。添加利多卡因还可显著降低兴奋副作用的发生率。
