Synthesis and biological activity of the metabolites of diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate (NO-1886).
作者信息
Goto K, Nakamura S, Morioka Y, Kondo M, Naito S, Tsutsumi K
机构信息
Laboratory of Drug Metabolism Research, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1996 Mar;44(3):547-51. doi: 10.1248/cpb.44.547.
PMID:8882452
Abstract
Five metabolites of diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate (NO-1886) (1) were synthesized to confirm their proposed structures. The metabolites (2-6) were found to be identical with the synthesized compounds. These metabolites were orally administered to Triton WR-1339-induced hypertriglyceridemic rats, and the plasma levels of triglycerides were measured to estimate lipoprotein lipase activity. All the metabolites showed lower potency than NO-1886.
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