Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, Brazil.
J Pharm Pharmacol. 2009 Dec;61(12):1673-9. doi: 10.1211/jpp/61.12.0013.
A significant association between the trace element selenium and hypercholesterolaemia has been reported. This study was designed to investigate a potential hypolipidaemic effect of diphenyl diselenide ((PhSe)(2)) in Triton WR-1339-induced hyperlipidaemia in mice.
Triton was administered intraperitoneally (400 mg/kg) to overnight-fasted mice to develop acute hyperlipidaemia. (PhSe)(2) was administered orally (10 mg/kg) 30 min before Triton. At 24 h after Triton injection, blood samples were collected to measure plasma lipid levels. The hepatic thiobarbituric acid reactive substances and ascorbic acid levels as well as catalase and glutathione peroxidase activity were recorded.
(PhSe)(2) administration significantly lowered total cholesterol, non-high-density lipoprotein-cholesterol and triglycerides, whilst it increased high-density lipoprotein-cholesterol levels in plasma of hyperlipidaemic mice. Neither oxidative stress nor the antioxidant effect of (PhSe)(2) was observed in the mouse liver in this experimental protocol.
These findings indicated that (PhSe)(2) was able to lower plasma lipid concentrations. Further studies are needed to elucidate the exact mechanism by which (PhSe)(2) exerted its hypolipidaemic effect in the management of hyperlipidaemia and atherosclerosis.
有报道称微量元素硒与高胆固醇血症之间存在显著关联。本研究旨在研究二苯二硒醚（(PhSe)2）在 Triton WR-1339 诱导的小鼠高脂血症中可能具有的降血脂作用。
将 Triton 通过腹腔注射（400mg/kg）给予禁食过夜的小鼠以诱导急性高脂血症。在给予 Triton 前 30 分钟，通过口服给予（PhSe）2（10mg/kg）。在 Triton 注射后 24 小时，采集血样以测量血浆脂质水平。记录肝组织丙二醛反应性物质和抗坏血酸水平以及过氧化氢酶和谷胱甘肽过氧化物酶活性。
（PhSe）2 给药可显著降低高脂血症小鼠血浆中的总胆固醇、非高密度脂蛋白胆固醇和甘油三酯，同时增加高密度脂蛋白胆固醇水平。在该实验方案中，（PhSe）2 既没有在小鼠肝脏中引起氧化应激，也没有表现出抗氧化作用。
这些发现表明（PhSe）2 能够降低血浆脂质浓度。需要进一步的研究来阐明（PhSe）2 发挥其降血脂作用以治疗高脂血症和动脉粥样硬化的确切机制。
