Moshé S L, Garant D S, Sperber E F, Velísková J, Kubová H, Brown L L
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Brain Dev. 1995;17 Suppl:61-72. doi: 10.1016/0387-7604(95)90074-8.
The substantia nigra pars reticulata (SNR) is a structure involved in the control of seizures, and its effects on seizures are age-dependent. GABAergic transmission in the SNR, mediated by GABAA receptors, influences seizure susceptibility. We have found that in the adult SNR there may be at least two segregated GABAA-sensitive SNR projection networks involved in regulating the SNR effects on seizures, perhaps reflecting the existence of an anticonvulsant and a proconvulsant network. The two networks with opposing effects on seizures originate from two topographically distinct regions. The anterior-medial region of the SNR is associated with anticonvulsant effects, whereas the posterior-dorsal region of the SNR is associated with proconvulsant effects. To explain ontogenic differences in the SNR effects on seizures, we hypothesize that the two functionally segregated networks which influence the expression of seizures may become segregated with maturation. The increased seizure susceptibility of rat pups may be due, in part, to delayed development of this anterior-medial SNR anticonvulsant network.
黑质网状部（SNR）是一个参与癫痫控制的结构，其对癫痫的影响具有年龄依赖性。由GABAA受体介导的SNR中的GABA能传递会影响癫痫易感性。我们发现，在成年SNR中，可能至少存在两个分离的对GABAA敏感的SNR投射网络，它们参与调节SNR对癫痫的影响，这可能反映了抗惊厥网络和促惊厥网络的存在。这两个对癫痫具有相反作用的网络起源于两个在地形上不同的区域。SNR的前内侧区域与抗惊厥作用相关，而SNR的后背侧区域与促惊厥作用相关。为了解释SNR对癫痫影响的个体发育差异，我们假设影响癫痫发作表达的两个功能分离的网络可能会随着成熟而分离。幼鼠癫痫易感性增加可能部分归因于这个前内侧SNR抗惊厥网络的发育延迟。
