Department of Neurology, University of Virginia, P.O. Box 800394, Charlottesville, VA 22908-0394, USA.
Exp Neurol. 2013 Jun;244:67-74. doi: 10.1016/j.expneurol.2012.01.028. Epub 2012 Feb 8.
Seizures occur in groups of neurons and involve complex interactions across several regions. The focus of much epilepsy research has been on changes in single neuronal populations but the interpretation of the implications of these changes is often limited by not being able to place those observed changes appropriately in the overall function of the brain. Understanding regional interactions at the beginning and during the evolution of a seizure may help place the changes in the appropriate context of the pathophysiology of epilepsy and guide us in identifying more effective therapies. In this paper we will focus on the circuits that support the different stages of seizures. Although we are far from knowing how the system works to initiate and spread seizures, we hope to provide a framework upon which we can place cellular changes. The concepts of seizure focus, initiating seizure circuits, paths of spread and neuromodulatory centers will be used to develop a system's view of epilepsy.
癫痫发作发生在神经元群中，并涉及多个区域的复杂相互作用。许多癫痫研究的重点都放在单个神经元群体的变化上，但由于无法将观察到的变化恰当地置于大脑的整体功能中，因此对这些变化的解释往往受到限制。了解癫痫发作开始和发展过程中的区域相互作用，可能有助于将这些变化置于癫痫病理生理学的适当背景下，并指导我们识别更有效的治疗方法。在本文中，我们将重点关注支持癫痫发作不同阶段的回路。尽管我们还远不知道系统如何启动和传播癫痫发作，但我们希望提供一个可以放置细胞变化的框架。癫痫发作焦点、起始癫痫发作回路、传播路径和神经调节中心的概念将被用于开发癫痫的系统观。
