Nunes J F, Fonseca I, Soares J
Departmento de Patologia Morfológica, Instituto Português de Oncologia de Francisco Gentil, Lisboa, Portugal.
Ultrastruct Pathol. 1996 Sep-Oct;20(5):443-9. doi: 10.3109/01913129609016347.
Helioid bodies are exceedingly rare, intranuclear, rounded inclusions with peripheral radiating filaments. These structures, which were formerly observed in only three cases of proliferative breast epithelial lesions, appeared in 0.5-1% of the neoplastic cells of a case of dedifferentiated acinic cell carcinoma of the parotid gland. Helioid bodies are related to rough endoplasmic reticulum cisternae, which suggests that they are the result of the condensation and partial crystallization of their contents when sequestrated into the nuclear compartment of the cell. The presence of helioid bodies may be related to secretory dysfunction of the tumor cells associated with the process of neoplastic dedifferentiation.
螺旋体样小体极为罕见，是位于细胞核内、带有周边放射状细丝的圆形包涵体。这些结构以前仅在3例增生性乳腺上皮病变中观察到，而在1例腮腺去分化腺泡细胞癌的肿瘤细胞中，有0.5%-1%的细胞出现了螺旋体样小体。螺旋体样小体与粗面内质网池有关，这表明它们是被隔离到细胞核内时其内容物浓缩和部分结晶的结果。螺旋体样小体的存在可能与肿瘤细胞的分泌功能障碍有关，而这种功能障碍与肿瘤去分化过程相关。
