De Salles A A, Solberg T D, Mischel P, Massoud T F, Plasencia A, Goetsch S, De Souza E, Viñuela F
Division of Neurosurgery, University of California at Los Angeles, School of Medicine, USA.
AJNR Am J Neuroradiol. 1996 Sep;17(8):1451-8.
To study the effects of single-dose radiation on the porcine rete mirabile, a tangle of microvessels that mimics human arteriovenous malformations of the brain.
Eight retia mirabilia received a single dose of radiation under stereotactic location with digital angiography and CT. The following doses were applied: 20, 30, 40, 50, 60, 70, 80, and 90 Gy. The animals were followed up for a period of 7 months. Findings at neurologic examination, serial angiography, and histopathologic examination were analyzed.
Progressive occlusion as observed by angiography corresponded to the histopathologic finding of intimal hyperplasia; that is, marked thickening of the vessel wall, progressing to occlusion of the vascular lumen, and associated thrombosis. A direct dose response was noted for these changes. Neurologic findings were related to the dose distribution and to histologic findings in structures adjacent to the rete mirabile.
The rete mirabile is an excellent model by which to study the radiologic and histologic effects of single-dose radiation to the microvasculature of the central nervous system.
研究单剂量辐射对猪奇网的影响，猪奇网是一种微血管缠结，类似于人类脑动静脉畸形。
八只奇网在立体定向定位下接受单剂量辐射，采用数字血管造影和CT。应用以下剂量：20、30、40、50、60、70、80和90 Gy。对动物进行7个月的随访。分析神经学检查、系列血管造影和组织病理学检查结果。
血管造影观察到的进行性闭塞与内膜增生的组织病理学发现相对应，即血管壁明显增厚，进展为血管腔闭塞，并伴有血栓形成。注意到这些变化存在直接的剂量反应。神经学发现与剂量分布以及奇网相邻结构的组织学发现有关。
奇网是研究单剂量辐射对中枢神经系统微血管的放射学和组织学影响的极佳模型。
