Raj Jude Amal, Stoodley Marcus
The Australian School of Advanced Medicine, Macquarie University, NSW 2109, Australia.
Vet Sci. 2015 Jun 19;2(2):97-110. doi: 10.3390/vetsci2020097.
Arteriovenous malformations (AVMs) are congenital lesions that cause brain haemorrhage in children and young adults. Current treatment modalities include surgery, radiosurgery and embolization. These treatments are generally effective only for small AVMs. Over one third of AVMs cannot be treated safely and effectively with existing options. Several animal models have been developed with the aims of understanding AVM pathophysiology and improving treatment. No animal model perfectly mimics a human AVM. Each model has limitations and advantages. Models contribute to the understanding of AVMs and hopefully to the development of improved therapies. This paper reviews animal models of AVMs and their advantages and disadvantages.
动静脉畸形（AVM）是导致儿童和年轻人脑出血的先天性病变。目前的治疗方式包括手术、放射外科和栓塞。这些治疗通常仅对小型AVM有效。超过三分之一的AVM无法通过现有方法安全有效地治疗。为了理解AVM的病理生理学并改进治疗，已经开发了几种动物模型。没有一种动物模型能完美模拟人类AVM。每种模型都有局限性和优点。这些模型有助于理解AVM，并有望推动改进疗法的开发。本文综述了AVM的动物模型及其优缺点。
