Wood F M, Stoner M
Royal Perth and Princess Margaret Hospital, Burn Unit, University of Western Australia, Australia.
Burns. 1996 Sep;22(6):459-62. doi: 10.1016/0305-4179(95)00178-6.
There is increasing evidence from the scientific literature that the developing epithelial basement membrane has the potential to influence the underlying dermis. The most rapidly dividing and active cell within the skin complex is the basal cell of the epidermis. The basal cell is well known to produce numerous protein factors which influence cellular growth and differentiation. The underlying dermal fibroblasts, by comparison, are relatively static. The concept that basal cells have an influence on the dermal and overall skin environment via the extracellular expression of proteins in the extracellular matrix, is gaining increased interest. A hypertrophic scar is a dermal phenomenon resulting from an imbalance in collagen production and maturation. Although the collagen is produced by the fibroblast, the extracellular matrix is an area where the epidermal cells have a potential influence. It is therefore the purpose of this paper to explore the idea that the cultured epithelial autograft may have an influence on the quality of scarring.
科学文献中有越来越多的证据表明，正在发育的上皮基底膜有可能影响其下方的真皮层。皮肤复合体中分裂最快且最活跃的细胞是表皮的基底细胞。众所周知，基底细胞会产生多种影响细胞生长和分化的蛋白质因子。相比之下，下方的真皮成纤维细胞相对静止。基底细胞通过细胞外基质中蛋白质的细胞外表达对真皮和整体皮肤环境产生影响这一概念正越来越受到关注。肥厚性瘢痕是一种由于胶原蛋白生成和成熟失衡导致的真皮现象。虽然胶原蛋白是由成纤维细胞产生的，但细胞外基质是表皮细胞可能产生影响的一个区域。因此，本文的目的是探讨培养的上皮自体移植可能对瘢痕形成质量产生影响这一观点。
