意大利佛罗伦萨人群中白喉免疫力的低流行率。

Low prevalence of diphtheria immunity in the population of Florence, Italy.

作者信息

Comodo N, Bonanni P, Lo Nostro A, Tiscione E, Mannelli F, Tomei A

机构信息

Public Health and Epidemiology Department, University of Florence, Italy.

出版信息

Eur J Epidemiol. 1996 Jun;12(3):251-5. doi: 10.1007/BF00145414.

DOI:10.1007/BF00145414

PMID:8884192

Abstract

A seroepidemiological study was conducted in 1994 on a representative sample of the population of Florence in order to verify the immunity coverage against diphtheria. Subjects were divided according to sex and age class. Sera from each selected class were at least 1.5/1000 of the residing population. Diphtheria antitoxin was titrated using a quantitative ELISA test. The results show an overall adjusted prevalence of diphtheria immunity (> or = 0.01 IU/ml) equal to 63.7%. Subjects of younger age classes have good protection levels (85.5% immune under 30 years), while only half individuals aged > or = 50 years have antibody titres > or = 0.01 IU/ml. Full protection (antibody titre > or = 0.1 IU/ml) was detected only in a very small proportion of those aged > or = 40 years. Our data show (1) how a recrudescence of diphtheria could theoretically take place in older subjects living in Italy, and (2) stress the importance of periodical re-vaccination of adults.

摘要

1994年，针对佛罗伦萨有代表性的人群样本开展了一项血清流行病学研究，以核实对白喉的免疫覆盖率。研究对象按性别和年龄组进行划分。每个选定组别的血清至少占常住人口的1.5/1000。采用定量酶联免疫吸附测定试验对白喉抗毒素进行滴定。结果显示，白喉免疫的总体校正患病率（≥0.01 IU/ml）为63.7%。年龄较小的组别具有良好的保护水平（30岁以下人群中85.5%具有免疫力），而年龄≥50岁的人群中只有半数的抗体滴度≥0.01 IU/ml。仅在极小比例的年龄≥40岁的人群中检测到完全保护（抗体滴度≥0.1 IU/ml）。我们的数据表明：（1）理论上，意大利老年人群体中可能会出现白喉复发情况；（2）强调了对成年人进行定期重新接种疫苗的重要性。