意大利14至30岁年龄组的白喉抗毒素水平。

Diphtheria antitoxin levels in the 14-30-year age group in Italy.

作者信息

Mastroeni I, Patti A M, Santi A L, Vescia N, Bocchini S, Bagnod S, Ciapetti C, Fara G M

机构信息

Department of Basic and Applied Biology, University of L'Aquila, Italy.

出版信息

Eur J Epidemiol. 1998 Oct;14(7):683-6. doi: 10.1023/a:1007479125558.

DOI:10.1023/a:1007479125558

PMID:9849829

Abstract

In order to verify diphtheria immunity a seroepidemiological survey was performed in 1996-1997. Serum samples were obtained from 501 subjects 14 years old, recruited at 8 schools in Rome, and from 490 subjects 20-30 years old recruited from 15 Italian regions. Serum diphtheria antitoxin was titrated using the Vero cell assay. The minimum protection level of antitoxin was set at 0.01 IU ml-1. The results show that the younger population have a good immunity to diphtheria while a large proportion of young adults is devoid of protective levels of diphtheria antitoxin. Out of the 501 subjects 14 years old, 495 (98.8%) had a diphtheria antitoxin titre > or = 0.01 IU ml(-1). Only 6 (1.2%) teenagers were susceptible. Out of the 490 subjects 20-30 years old, 109 (22.2%) were susceptible, 381 (77.8%) had a diphtheria antitoxin titre > or = 0.01 IU ml(-1). The data stress for booster immunization at the end of junior high school.

摘要

为了验证白喉免疫力，于1996 - 1997年进行了一项血清流行病学调查。血清样本取自罗马8所学校招募的501名14岁受试者，以及从意大利15个地区招募的490名20 - 30岁受试者。使用Vero细胞试验滴定血清白喉抗毒素。抗毒素的最低保护水平设定为0.01 IU/ml。结果表明，较年轻人群对白喉有良好的免疫力，而很大一部分年轻人缺乏白喉抗毒素的保护水平。在501名14岁受试者中，495名（98.8%）白喉抗毒素滴度≥0.01 IU/ml。只有6名（1.2%）青少年易感。在490名20 - 30岁受试者中，109名（22.2%）易感，381名（77.8%）白喉抗毒素滴度≥0.01 IU/ml。数据强调在初中结束时进行加强免疫。