Popović M, Jovanova-Nesić K, Popović N, Bokonjić D, Dobrić S, Rosić N, Rakić L
Immunology Research Center Branislav Janković, Belgrade, FR Yugoslavia.
Int J Neurosci. 1996 Sep;86(3-4):281-99. doi: 10.3109/00207459608986719.
Ten days after bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM) we tested behavioral (spontaneous motor activity, acquisition and performance of two-way active avoidance, fear-response in open field test, foot shock induced aggression, depression-response in learned helplessness test) and adaptive status (body temperature at standard, hot and cold environment as well as cold restraint-induced gastric lesions) in adult male Wistar rats. Compared to intact control and sham-operated rats, the bilateral NBM-lesioned rats showed the significant impairment of learning behavior and reduced fear, aggression and depression as well as altered body temperature at standard and stressed conditions. Namely, it was established that body temperature in NBM-lesioned rats was significantly lower at standard laboratory conditions, but in these rats body temperature significantly was raised after exposing to cold and hot environment. On the other hand, spontaneous motor activity and number and length of cold restraint-induced gastric lesions (erosions and petechiae) in NBM-lesioned rats were similarly to those in both controls. It could be concluded that NBM plays a significant role in cognitive, emotional and adaptive processes in the rats.
在双侧基底核大细胞部（NBM）进行电解损伤十天后，我们对成年雄性Wistar大鼠的行为（自发运动活动、双向主动回避的习得与表现、旷场试验中的恐惧反应、足部电击诱发的攻击行为、习得性无助试验中的抑郁反应）和适应性状态（标准、热和冷环境下的体温以及冷束缚诱发的胃损伤）进行了测试。与完整对照大鼠和假手术大鼠相比，双侧NBM损伤的大鼠在学习行为上表现出显著损伤，恐惧、攻击和抑郁反应降低，并且在标准和应激条件下体温发生改变。具体而言，已确定NBM损伤大鼠在标准实验室条件下体温显著降低，但在暴露于冷热环境后，这些大鼠的体温显著升高。另一方面，NBM损伤大鼠的自发运动活动以及冷束缚诱发的胃损伤（糜烂和瘀点）的数量和长度与两种对照大鼠相似。可以得出结论，NBM在大鼠的认知、情感和适应性过程中起重要作用。
