文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Timbrell J A, Mitchell J R

Xenobiotica. 1977 Jul;7(7):415-23. doi: 10.3109/00498257709035801.

The influence of microsomal enzyme inducers and inhibitors on the metabolism of [U-14C]benzene in the rat was examined. 2. Pre-treatment of animals with the inhibitors piperonyl butoxide and cobaltous chloride tended to reduce the urinary excretion of metabolites in 24 h but increase the overall urinary excretion. Piperonyl butoxide tended to increase expired benzene. 3. Pre-treatment of animals with the inducer phenobarbital tended to increase urinary excretion of metabolites but decrease expired benzene, as did pre-treatment with benzene itself. 4. All pre-treatments appeared to increase the excretion of phenolic glucuronides, particularly benzene pre-treatment. Phenobarbital and benzene pre-treatment tended to increase phenylmercapturic acid excretion and benzene pre-treatment markedly increased excretion of quinol. 5. The results are discussed in relation to the effect of microsomal enzyme inhibitors and inducers on benzene-induced bone marrow toxicity.

研究了微粒体酶诱导剂和抑制剂对大鼠体内[U-14C]苯代谢的影响。2. 用抑制剂胡椒基丁醚和氯化钴对动物进行预处理，往往会减少24小时内代谢物的尿排泄，但会增加总的尿排泄。胡椒基丁醚往往会增加呼出的苯。3. 用诱导剂苯巴比妥对动物进行预处理，往往会增加代谢物的尿排泄，但会减少呼出的苯，苯本身预处理也有同样的效果。4. 所有预处理似乎都会增加酚类葡糖醛酸苷的排泄，尤其是苯预处理。苯巴比妥和苯预处理往往会增加苯硫醇尿酸的排泄，而苯预处理则会显著增加喹啉的排泄。5. 结合微粒体酶抑制剂和诱导剂对苯诱导的骨髓毒性的影响对结果进行了讨论。

Timbrell J A, Mitchell J R

Xenobiotica. 1977 Jul;7(7):415-23. doi: 10.3109/00498257709035801.

The influence of microsomal enzyme inducers and inhibitors on the metabolism of [U-14C]benzene in the rat was examined. 2. Pre-treatment of animals with the inhibitors piperonyl butoxide and cobaltous chloride tended to reduce the urinary excretion of metabolites in 24 h but increase the overall urinary excretion. Piperonyl butoxide tended to increase expired benzene. 3. Pre-treatment of animals with the inducer phenobarbital tended to increase urinary excretion of metabolites but decrease expired benzene, as did pre-treatment with benzene itself. 4. All pre-treatments appeared to increase the excretion of phenolic glucuronides, particularly benzene pre-treatment. Phenobarbital and benzene pre-treatment tended to increase phenylmercapturic acid excretion and benzene pre-treatment markedly increased excretion of quinol. 5. The results are discussed in relation to the effect of microsomal enzyme inhibitors and inducers on benzene-induced bone marrow toxicity.

研究了微粒体酶诱导剂和抑制剂对大鼠体内[U-14C]苯代谢的影响。2. 用抑制剂胡椒基丁醚和氯化钴对动物进行预处理，往往会减少24小时内代谢物的尿排泄，但会增加总的尿排泄。胡椒基丁醚往往会增加呼出的苯。3. 用诱导剂苯巴比妥对动物进行预处理，往往会增加代谢物的尿排泄，但会减少呼出的苯，苯本身预处理也有同样的效果。4. 所有预处理似乎都会增加酚类葡糖醛酸苷的排泄，尤其是苯预处理。苯巴比妥和苯预处理往往会增加苯硫醇尿酸的排泄，而苯预处理则会显著增加喹啉的排泄。5. 结合微粒体酶抑制剂和诱导剂对苯诱导的骨髓毒性的影响对结果进行了讨论。