Kiyono Y, Shibamoto T, Tanaka S, Wang H G, Nakatsuchi Y, Koyama S
Department of Physiology, Shinshu University School of Medicine, Nagano, Japan.
J Auton Nerv Syst. 1996 Aug 27;60(1-2):76-82. doi: 10.1016/0165-1838(96)00039-2.
The present study was designed to determine whether regional differences exist in sympathetic responses to somatic nerve stimulation and whether the baroreceptor reflex modulates this somato-sympathetic reflex. The cardiac (CNA), renal (RNA), hepatic (HNA), splenic (SpNA) and adrenal (AdNA) sympathetic postganglionic nerve activities (SNA) were simultaneously recorded in anesthetized dogs with intact (n = 7) or bilaterally sectioned (n = 8) carotid sinus and vagus nerves. In the intact group, electrical stimulation of the left peroneal nerve at low intensity and low frequency (5 V, 5 Hz) produced a fall in mean arterial pressure (MAP) (-9.7 +/- 2.7 mmHg) and a decrease in each SNA with no regional differences RNA (79.2 +/- 8.5%), AdNA (82.7 +/- 5.4%), HNA (89.4 +/- 4.5%), CNA (87.5 +/- 3.5%), SpNA (84.2 +/- 3.2%). In contrast, stimulation at high intensity and high frequency (25 V, 50 Hz) produced a rise in MAP (+21.4 +/- 3.8 mmHg) and increases in SNA with quantitative predominance of RNA (178.6 +/- 13.6%) and AdNA (158.3 +/- 16.1%) over HNA (129.0 +/- 4.2%), CNA (117.7 +/- 7.6%), and SpNA (112.0 +/- 6.2%). Similar responses were observed when the left ulnar nerve was stimulated. The changes in SNA (delta SNA) at 10 s after the start of stimulation were plotted as a function of the changes in MAP (delta MAP) and the regression curves were determined. The best fit regression curve was a logistic sigmoid curve in the intact group and a linear one in the baroreceptor denervated group. Furthermore, delta RNA/delta MAP and delta AdNA/delta MAP during the somato-pressor response were significantly smaller in the intact group than in the denervated group. In conclusion, there are regional differences of sympathetic response during the somato pressor response but not during somato depressor response. The baroreceptor reflex may suppress the somato-sympathetic reflex of RNA and AdNA.
本研究旨在确定躯体神经刺激的交感反应是否存在区域差异，以及压力感受器反射是否调节这种躯体 - 交感反射。在麻醉的犬类中，同时记录完整（n = 7）或双侧切断（n = 8）颈动脉窦和迷走神经情况下的心脏（CNA）、肾脏（RNA）、肝脏（HNA）、脾脏（SpNA）和肾上腺（AdNA）交感神经节后神经活动（SNA）。在完整组中，以低强度和低频（5 V，5 Hz）电刺激左侧腓总神经，导致平均动脉压（MAP）下降（-9.7±2.7 mmHg），各SNA均降低，且无区域差异，RNA（79.2±8.5%）、AdNA（82.7±5.4%）、HNA（89.4±4.5%）、CNA（87.5±3.5%）、SpNA（84.2±3.2%）。相反，以高强度和高频（25 V，50 Hz）刺激时，MAP升高（+21.4±3.8 mmHg），SNA增加，其中RNA（178.6±13.6%）和AdNA（158.3±16.1%）在数量上比HNA（129.0±4.2%）、CNA（117.7±7.6%）和SpNA（112.0±6.2%）更占优势。刺激左侧尺神经时观察到类似反应。将刺激开始后10 s时SNA的变化（ΔSNA）作为MAP变化（ΔMAP）的函数进行绘制，并确定回归曲线。完整组中最佳拟合回归曲线为逻辑S形曲线，而压力感受器去神经支配组为线性曲线。此外，在躯体升压反应期间，完整组的ΔRNA/ΔMAP和ΔAdNA/ΔMAP显著小于去神经支配组。总之，在躯体升压反应期间交感反应存在区域差异，而在躯体降压反应期间则不存在。压力感受器反射可能会抑制RNA和AdNA的躯体 - 交感反射。
