在瑞典南部一个静脉血栓形成高发地区，导致APC抵抗的FVR506Q突变的高流行率。 - Suppr

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超能文献

High prevalence of the FVR506Q mutation causing APC resistance in a region of southern Sweden with a high incidence of venous thrombosis.

作者信息

Zöller B, Norlund L, Leksell H, Nilsson J E, von Schenck H, Rosén U, Jepsson J O, Dahlbäck B

出版信息

Thromb Res. 1996 Sep 15;83(6):475-7. doi: 10.1016/0049-3848(96)00157-0.

DOI:10.1016/0049-3848(96)00157-0

PMID:8885142

Abstract

摘要

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High prevalence of the FVR506Q mutation causing APC resistance in a region of southern Sweden with a high incidence of venous thrombosis.在瑞典南部一个静脉血栓形成高发地区，导致APC抵抗的FVR506Q突变的高流行率。

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Inherited resistance to activated protein C caused by presence of the FV:Q506 allele as a basis of venous thrombosis.

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Evaluation of original and modified APC-resistance tests in unselected outpatients with clinically suspected thrombosis and in healthy controls.

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Apparent different thrombotic tendency in patients with factor V Leiden and protein C deficiency due to selection of patients.由于患者选择因素，因子V莱顿突变和蛋白C缺乏症患者存在明显不同的血栓形成倾向。

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