Iida M, Aoyagi K, Fujimura Y, Matsumoto T, Hizawa K, Nakamura S
Department of Medicine, Kawasaki Medical School, Kurashiki, Japan.
Gastrointest Endosc. 1996 Sep;44(3):305-8. doi: 10.1016/s0016-5107(96)70169-4.
Although duodenal adenomas are very common in familial adenomatous polyposis, we wished to emphasize our experience with finding nonpolypoid adenomas in the duodenum of patients with this disease.
Duodenoscopy was performed in 23 patients with an established diagnosis of familial adenomatous polyposis or Gardner's syndrome.
Endoscopy revealed single or multiple nonpolypoid adenomas of the duodenum in 7 patients (30%). The lesions were smaller than 5 mm and were endoscopically recognized as flat or depressed reddish lesions; one lesion was completely flat and the remaining lesions were flat-topped elevations with a central depression. All of the lesions were histologically diagnosed as tubular adenoma with moderate epithelial atypia.
These findings suggest that duodenal nonpolypoid adenomas are common in familial adenomatous polyposis or Gardner's syndrome and that careful surveillance endoscopy seems necessary in patients with this disease.
尽管十二指肠腺瘤在家族性腺瘤性息肉病中非常常见，但我们希望强调我们在患有这种疾病的患者十二指肠中发现非息肉样腺瘤的经验。
对23例已确诊为家族性腺瘤性息肉病或加德纳综合征的患者进行了十二指肠镜检查。
内镜检查发现7例患者（30%）十二指肠有单个或多个非息肉样腺瘤。病变小于5毫米，在内镜下被识别为扁平或凹陷的红色病变；1个病变完全扁平，其余病变为中央凹陷的平顶隆起。所有病变经组织学诊断为中度上皮异型性的管状腺瘤。
这些发现表明，十二指肠非息肉样腺瘤在家族性腺瘤性息肉病或加德纳综合征中很常见，对于患有这种疾病的患者，似乎有必要进行仔细的监测内镜检查。
