Falleroni A E, Zeiss C R
Lakeside Veterans Medical Affairs Center, Chicago, Illinois, USA.
Ann Allergy Asthma Immunol. 1996 Oct;77(4):298-302. doi: 10.1016/S1081-1206(10)63324-8.
Soybean is a common food allergen. It can cause Type 1 allergy (IgE-mediated) symptoms from its ingestion, as well as from inhalation of its dust.
To report a case of allergy in a child from the inhalation of soybean dust from a bean bag and the course of this allergy over time.
Case report; routine skin testing and laboratory tests; bean bag challenge studies; special studies with saline extracts of the bean bag soybeans.
A 6-year-old boy with a 1-year history of allergic rhinitis noted symptoms of urticaria, eyelid angioedema, and mild respiratory distress while at school playing with a bean bag containing soybeans. Skin tests revealed positive reactions to commercial soybean extract and bean bag soybean extracts. Bean bag challenge was also positive. The patient's serum was able to transfer this sensitivity by the Prausnitz-Küstner (P-K) reaction. RAST and polystyrene tube radioimmunoassay techniques, however, did not detect specific IgE to soybean allergens. During follow-up, the patient developed allergy symptoms with ingestion of other beans. This latter allergy lasted for only 2 years, but the bean bag allergy was still present 4 years later (bean bag challenge). The patient returned at age 19 for recurrence of his allergic rhinitis and de novo asthma. Repeat bean bag challenge at age 24 was negative.
To the best of our knowledge, this is the first reported childhood case of IgE-mediated allergy from soybean dust during play with a bean bag containing dry soybeans. Over time, despite the loss of this sensitivity, he developed asthma, another IgE-mediated illness.
大豆是一种常见的食物过敏原。摄入大豆或吸入其粉尘可引发1型过敏（IgE介导）症状。
报告一例儿童因吸入豆袋中的大豆粉尘而过敏及其随时间发展的病程。
病例报告；常规皮肤试验和实验室检查；豆袋激发试验；用豆袋中大豆的盐水提取物进行的专项研究。
一名有1年变应性鼻炎病史的6岁男孩，在学校玩装有大豆的豆袋时出现荨麻疹、眼睑血管性水肿和轻度呼吸窘迫症状。皮肤试验显示对市售大豆提取物和豆袋大豆提取物呈阳性反应。豆袋激发试验也呈阳性。患者血清能够通过普劳斯尼茨－屈斯特纳（P-K）反应传递这种敏感性。然而，放射性变应原吸附试验（RAST）和聚苯乙烯管放射免疫测定技术未检测到针对大豆过敏原的特异性IgE。在随访期间，患者摄入其他豆类时出现过敏症状。后一种过敏仅持续了2年，但4年后豆袋过敏仍然存在（豆袋激发试验）。患者19岁时因变应性鼻炎复发和新发哮喘前来就诊。24岁时重复进行豆袋激发试验结果为阴性。
据我们所知，这是首例报告的儿童在玩装有干大豆的豆袋时因大豆粉尘导致IgE介导过敏的病例。随着时间推移，尽管这种敏感性消失，但他患上了哮喘，这是另一种IgE介导的疾病。
