Sylvestre D L, Ravetch J V
Division of Molecular Biology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Immunity. 1996 Oct;5(4):387-90. doi: 10.1016/s1074-7613(00)80264-2.
Antibody-antigen complexes are central to the inflammatory response and are implicated in the development of such diverse diseases as systemic lupus erythematosis, rheumatoid arthritis, immune glomerulonephritis, and vasculitis. We recently demonstrated that experimental immune complex-mediated injury in mice, as modeled by the cutaneous Arthus reaction, requires receptors for the Fc portion of the antibody and is unaffected by deficiencies in complement components. However, the responsible cell type(s) and Fc receptor(s) were not known. We now demonstrate by differential reconstitution in vivo that Fc gamma RIII on mast cells is necessary for this inflammatory response. We propose a general model of antibody-mediated diseases as an immunopathologic spectrum whose specific manifestations are determined by the Fc receptor and cell type engaged.
抗体 - 抗原复合物是炎症反应的核心，并与多种疾病的发生发展有关，如系统性红斑狼疮、类风湿性关节炎、免疫性肾小球肾炎和血管炎。我们最近证明，以皮肤阿瑟斯反应为模型的小鼠实验性免疫复合物介导的损伤需要抗体Fc部分的受体，并且不受补体成分缺陷的影响。然而，相关的细胞类型和Fc受体尚不清楚。我们现在通过体内差异重建证明，肥大细胞上的FcγRIII对于这种炎症反应是必需的。我们提出了一个抗体介导疾病的通用模型，作为一种免疫病理谱，其具体表现由所涉及的Fc受体和细胞类型决定。
