Anniko M, Wersäll J
Acta Otolaryngol. 1977 May-Jun;83(5-6):429-40. doi: 10.3109/00016487709128868.
Atoxyl administration to guinea pigs may cause vesicular degeneration of both the secretory and the sensory regions of the cristae ampullares and macula utriculi. Some of the severely damaged secretory cells were even expelled from the surface into the endolymphatic space. The nerve chalices of type I hair cells disintegrated. The degeneration of the secretory region will thus block the endolymph circulation and the electrolyte balance is likely to collapse. Whether hair cell degeneration can best be explained on this basis (indirect atoxyl effect) or by a direct action of atoxyl on the hair cells and the nerve chalices of type I hair cells is discussed.
给豚鼠注射阿托克西尔可能会导致壶腹嵴和椭圆囊斑的分泌区域和感觉区域出现水泡样变性。一些严重受损的分泌细胞甚至从表面被排入内淋巴间隙。I型毛细胞的神经杯解体。分泌区域的变性会因此阻碍内淋巴循环，电解质平衡可能会崩溃。本文讨论了毛细胞变性最好是基于此（阿托克西尔的间接作用）来解释，还是由阿托克西尔对毛细胞和I型毛细胞的神经杯的直接作用来解释。
