Ruder A M
Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA.
Occup Med. 1996 Jul-Sep;11(3):487-512.
The author outlines the methods by which the International Agency for Research on Cancer evaluates study design and results when it reviews epidemiologic studies to determine carcinogenicity and mutagenicity. The chapter concludes with an extensive series of tables summarizing (1) the tests relevant to mutagenicity and (2) the IARC rating system for carcinogens, categorizing industrial and agricultural chemicals according to evidence of mutagenicity.
作者概述了国际癌症研究机构在审查流行病学研究以确定致癌性和致突变性时评估研究设计和结果的方法。本章最后列出了一系列详尽的表格,总结了(1)与致突变性相关的测试,以及(2)国际癌症研究机构的致癌物评级系统,该系统根据致突变性证据对工业和农业化学品进行分类。