Dark F L, McGrath J J, Ron M A
Department of Psychiatry, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Aust N Z J Psychiatry. 1996 Aug;30(4):472-9. doi: 10.3109/00048679609065020.
To review the clinical features, neurobiological correlates and treatment of pathological laughing and crying.
Selective literature review.
Attacks of involuntary, irresistible laughing or crying have long been recognised as sequelae of brain damage. There is controversy about the clinical features of these attacks, the stimuli that provoke them and their relation to affective disorder. The pathophysiology of pathological laughing and crying is still unclear. It can occur in the presence of focal as well as diffuse brain disease. Treatment with antidepressant medications has been found to be of benefit in patients with cerebrovascular disease and multiple sclerosis.
Clinicians should remain vigilant for these symptoms, and offer effective treatments, such as antidepressants, where indicated. Further research is needed to delineate the underlying neurobiological correlates of pathological laughing and crying. The efficacy of both pharmacological and non-pharmacological interventions requires critical evaluation.
回顾病理性哭笑的临床特征、神经生物学关联及治疗方法。
进行选择性文献综述。
不由自主、无法抑制的哭笑发作长期以来一直被视为脑损伤的后遗症。关于这些发作的临床特征、诱发因素及其与情感障碍的关系存在争议。病理性哭笑的病理生理学仍不清楚。它可发生于局灶性及弥漫性脑疾病患者中。已发现抗抑郁药物治疗对脑血管疾病和多发性硬化症患者有益。
临床医生应对这些症状保持警惕，并在有指征时提供有效的治疗方法，如抗抑郁药。需要进一步研究以明确病理性哭笑潜在的神经生物学关联。药物和非药物干预的疗效都需要进行严格评估。
