Lee J W
Graylands Hospital, Mt Claremont, Australia.
Aust N Z J Psychiatry. 1996 Aug;30(4):553-6. doi: 10.3109/00048679609065032.
A case of XXYY associated with schizophrenia is presented.
A European male with tall stature, hypogonadism, and mild grade intellectual handicap with significantly lower verbal than performance Intelligence Quotient (IQ) exhibited features of chronic paranoid schizophrenia, along with impulsive aggression.
A trial of testosterone replacement exacerbated aggression. Psychotic symptoms persisted despite antipsychotic therapy.
This is perhaps the first report of the XXYY syndrome associated with schizophrenia. The psychosis occurs more often in XXY and XXX than normal subjects, providing a clue to locating a gene predisposing to schizophrenia.
报告一例与精神分裂症相关的XXYY综合征病例。
一名欧洲男性，身材高大，性腺功能减退，有轻度智力障碍，言语智商显著低于操作智商，表现出慢性偏执型精神分裂症的特征，伴有冲动攻击性。
睾酮替代治疗试验加重了攻击性。尽管进行了抗精神病治疗，精神病症状仍持续存在。
这可能是首例与精神分裂症相关的XXYY综合征报告。与正常受试者相比，XXY和XXX个体中精神病的发生率更高，这为定位精神分裂症易感基因提供了线索。
