Mizeret J C, van den Bergh H E
Institute of Environmental Engineering, Swiss Federal Institute of Technology, Lausanne, Switzerland.
Lasers Surg Med. 1996;19(2):159-67. doi: 10.1002/(SICI)1096-9101(1996)19:2<159::AID-LSM6>3.0.CO;2-R.
A cylindrical light diffuser has been developed mainly for medical applications, including photodynamic therapy (PDT), in particular interstitial PDT, PDT of the bronchi, or intravascular PDT.
STUDY DESIGN/MATERIALS AND METHODS: The diffuser is based on a polymer optical fiber. The coupling of the light out of the core is controlled by the roughness mechanically induced on the surface of the core. The light is then isotropically diffused by a thin layer of a scattering medium. The active length can be 100 mm or more, whereas the outer diameter is 1 mm or less. The diffuser is flexible and can be introduced in tissue though a hypodermic needle.
The main property of this light diffuser is the homogeneity of the light intensity emitted along its whole active length and around its circumference (360 degrees). Various intensity profiles can be made, including M-shape profiles for a homogeneous irradiance (+/- 10%) at a certain depth in the tissue. Furthermore, the diffuser is essentially isotropic and its optical properties are hardly dependent on wavelength.
A diffuser for interstitial and intraluminal PDT has been developed. It is flexible, homogeneous, independent on wavelength, and can be made with a very high length-to-diameter ratio.
已开发出一种圆柱形光扩散器，主要用于医学应用，包括光动力疗法（PDT），尤其是间质光动力疗法、支气管光动力疗法或血管内光动力疗法。
研究设计/材料与方法：该光扩散器基于聚合物光纤。从纤芯输出的光的耦合由机械诱导在纤芯表面产生的粗糙度控制。然后，光由一层薄的散射介质进行各向同性扩散。有效长度可为100毫米或更长，而外径为1毫米或更小。该光扩散器是柔性的，可通过皮下注射针引入组织。
这种光扩散器的主要特性是沿其整个有效长度及其圆周（360度）发射的光强的均匀性。可以制作各种强度分布，包括在组织中特定深度处具有均匀辐照度（±10%）的M形分布。此外，该光扩散器基本上是各向同性的，其光学特性几乎不依赖于波长。
已开发出一种用于间质和腔内光动力疗法的光扩散器。它是柔性的、均匀的、不依赖于波长的，并且可以制成非常高的长径比。
