Razvi H A, Muschter R, Anson K, Vargas J C, Perlmutter A P
Department of Urology, New York Hospital-Cornell Medical Center, New York City 10021, USA.
Lasers Surg Med. 1996;19(2):184-9. doi: 10.1002/(SICI)1096-9101(1996)19:2<184::AID-LSM10>3.0.CO;2-7.
Research interests in laser prostatectomy continue to evaluate a variety of wavelengths and treatment parameters in an effort to optimize treatment. Recently, a semiconductor diode laser with a wavelength of 805 nm has become available for clinical use; however, free-beam noncontact applications were limited by the low power output (25 W). In this study in the canine prostate, the possible potentiating effects of intravenously administered indocyanine green (ICG) were evaluated with the 805 nm diode laser.
STUDY DESIGN/MATERIALS AND METHODS: A total of 16 fixed position, free-beam lasings were performed at 25 W for 60 sec in four dogs with eight lasings before and eight lasings after ICG administration. Endoscopic observations and measurements of lesion volumes were used to evaluate the laser-tissue interactions.
Prior to ICG administration, we observed that side fire irradiation produced primarily small coagulative lesions. Following ICG administration, however, immediate and more noticeable tissue vaporization occurred, although total lesion size was not increased. Pathologic review demonstrated less coagulation and hyperemia, but a larger vaporized cavity in the ICG treated tissue.
These findings suggest intravenous ICG alters laser-tissue interaction with the 805 nm diode laser in the canine prostate. The use of the 805 nm diode laser with enhancing chromophores deserves further investigation.
对激光前列腺切除术的研究兴趣持续聚焦于评估各种波长和治疗参数，以优化治疗效果。近来，一种波长为805纳米的半导体二极管激光已可供临床使用；然而，其非接触式自由光束应用受低功率输出（25瓦）限制。在这项针对犬前列腺的研究中，我们评估了静脉注射吲哚菁绿（ICG）对805纳米二极管激光可能产生的增效作用。
研究设计/材料与方法：对4只犬进行了总共16次固定位置的自由光束激光照射，功率为25瓦，每次照射60秒，其中8次在注射ICG前进行，8次在注射后进行。通过内镜观察和测量病变体积来评估激光与组织的相互作用。
在注射ICG前，我们观察到侧方照射主要产生小的凝固性病变。然而，注射ICG后，尽管病变总体大小未增加，但立即出现了更明显的组织汽化。病理检查显示，ICG处理的组织中凝固和充血较少，但汽化腔较大。
这些发现表明静脉注射ICG改变了805纳米二极管激光与犬前列腺组织的相互作用。使用805纳米二极管激光并结合增效发色团值得进一步研究。
