Greenwell T J, Wyman A, Rogers K
University Department of Surgery, Clinical Sciences Centre, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK.
Eur J Surg Oncol. 2001 Jun;27(4):368-72. doi: 10.1053/ejso.2001.1136.
A new technique of 805 nm semiconductor diode laser-tissue interaction potentiation using indocyanine green (ICG) as an exogenous chromophore has been assessed for use in the palliation of advanced gastrointestinal malignancy.
The tissue effects of ICG potentiated 805 nm laser were assessed both in-vivo using rat stomach and colon, and in vitro using normal and neoplastic human gastric and colonic mucosa.
Intravenous ICG did not potentiate the laser-tissue effects of the 805 nm laser in in-vivo studies. Local techniques of ICG application (submucosal injection +/- surface painting of 0.1% ICG solution) enhanced the total depth and diameter of laser induced thermal injury in all in-vitro tissues. Without ICG enhancement thermal tissue injury was minimal in normal gastric and colonic mucosa.
Local techniques of ICG application enhance laser induced thermal injury in normal and neoplastic gastric and colonic mucosa. This may permit targeting of 805 nm laser-tissue effects with minimal collateral damage during endoscopic laser palliation of advanced gastrointestinal malignancy.
一种以吲哚菁绿（ICG）作为外源性发色团的805纳米半导体二极管激光与组织相互作用增强新技术，已被评估用于晚期胃肠道恶性肿瘤的姑息治疗。
采用大鼠胃和结肠在体内评估ICG增强的805纳米激光对组织的影响，并采用正常和肿瘤性人胃及结肠黏膜在体外进行评估。
在体内研究中，静脉注射ICG并未增强805纳米激光对组织的作用。ICG局部应用技术（黏膜下注射±0.1%ICG溶液表面涂抹）增强了所有体外组织中激光诱导热损伤的总深度和直径。在没有ICG增强的情况下，正常胃和结肠黏膜的热组织损伤最小。
ICG局部应用技术增强了正常和肿瘤性胃及结肠黏膜中激光诱导的热损伤。这可能使在晚期胃肠道恶性肿瘤的内镜激光姑息治疗期间，以最小的附带损伤靶向805纳米激光与组织的作用。
