Elliott F A, Leonberg S C
Am J Med. 1977 Aug;63(2):208-14. doi: 10.1016/0002-9343(77)90234-0.
Biomicroscopic examination of the bulbar conjunctival vessels regularly discloses degenerative microangiopathy in patients with overt arteriosclerotic cerebral vascular disease. Examination of a group of normotensive nondiabetic adults aged 21 to 39 years disclosed similar but less severe changes in 56 per cent of the men and 26 per cent of the women. The incidence was higher (88 per cent of the men and 45 per cent of the women) in those with a strong family history of early death from arteriosclerotic disease. There was no consistent correlation between the severity of the microangiopathy and the values for hematocrit, cholesterol, triglycerides or blood pressure. Conjunctival microangiopathy, like atherosclerosis of larger vessels, starts in the second and third decades and advances with age. We suggest that microangiopathic changes in the conjunctival vessels may provide the first readily detectable evidence of degenerative vascular disease.
对患有明显动脉硬化性脑血管疾病患者的球结膜血管进行生物显微镜检查，经常会发现退行性微血管病。对一组年龄在21至39岁的血压正常的非糖尿病成年人进行检查发现，56%的男性和26%的女性有类似但程度较轻的变化。在有动脉硬化性疾病早亡家族史的人群中，这一发生率更高（88%的男性和45%的女性）。微血管病的严重程度与血细胞比容、胆固醇、甘油三酯或血压值之间没有一致的相关性。结膜微血管病与较大血管的动脉粥样硬化一样，始于二三十岁，并随着年龄的增长而进展。我们认为结膜血管的微血管病变可能是退行性血管疾病首个易于检测到的证据。
