Tsubota A, Kumada H, Chayama K, Arase Y, Saitoh S, Koida I, Murashima N, Suzuki Y, Kobayashi M, Takagi K, Kobayashi M, Ikeda K
Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan.
Dig Dis Sci. 1996 Oct;41(10):1925-32. doi: 10.1007/BF02093591.
To determine the contribution of virus-related factors to long-term remission of chronic hepatitis C infection, we analyzed viral type and viremia level in 185 patients who had undergone a six-month course of interferon-alpha therapy. These virus-related factors were measured by an enzyme-linked immunosorbent assay with use of viral type-specific antigens and the branched DNA (bDNA) signal amplification assay, respectively. Sustained and long-term sustained responses were achieved in 55% and 50% of the patients, respectively. Transient or no responses were observed in 30% and 15% of the patients, respectively. Thirty-five percent of viral type 1 patients and 82% of viral type 2 patients had long-term sustained responses. Forty-two percent of bDNA-positive and 71% of bDNA-negative patients experienced long-term sustained responses. On multivariate analysis, viral type, Knodell's intralobular score, and viremia level were strong independent predictors of long-term sustained response (P < 0.0001, = 0.0060, and 0.037, respectively). Viremia level, however, was a significant predictor only in viral type 1, not type 2, patients. The relation between pretreatment viremia level and response to interferon-alpha therapy in chronic hepatitis C differs in viral type 1 and 2 infections.
为了确定病毒相关因素对慢性丙型肝炎感染长期缓解的作用，我们分析了185例接受了为期6个月的α干扰素治疗患者的病毒类型和病毒血症水平。这些病毒相关因素分别通过使用病毒类型特异性抗原的酶联免疫吸附测定和分支DNA（bDNA）信号扩增测定来测量。分别有55%和50%的患者实现了持续和长期持续应答。分别有30%和15%的患者观察到短暂或无应答。1型病毒患者中有35%以及2型病毒患者中有82%获得了长期持续应答。bDNA阳性患者中有42%以及bDNA阴性患者中有71%经历了长期持续应答。多变量分析显示，病毒类型、Knodell小叶内评分和病毒血症水平是长期持续应答的强有力独立预测因素（P分别<0.0001、=0.0060和0.037）。然而，病毒血症水平仅是1型病毒而非2型病毒患者的显著预测因素。慢性丙型肝炎患者治疗前病毒血症水平与对α干扰素治疗反应之间的关系在1型和2型病毒感染中有所不同。
