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与牛血清白蛋白结合的孕酮和3α-雄烷二醇应用于中脑腹内侧核和视前区时会影响发情行为。

Progesterone and 3 alpha-androstanediol conjugated to bovine serum albumin affects estrous behavior when applied to the MBH and POA.

作者信息

Frye C A, Van Keuren K R, Rao P N, Erskine M S

机构信息

Department of Biology, Boston University, USA.

出版信息

Behav Neurosci. 1996 Jun;110(3):603-12. doi: 10.1037//0735-7044.110.3.603.

DOI:10.1037//0735-7044.110.3.603
PMID:8889005
Abstract

Ovariectomized rats with cannula over the medial basal hypothalamus (MBH) received implants of 3 alpha-diol conjugated to bovine serum albumin (BSA; 3 alpha-diol:BSA), free 3 alpha-diol diluted with BSA (3 alpha-diol&BSA), progesterone (P) conjugated to BSA (P:BSA), free P diluted with BSA (P&BSA), or BSA alone. 3 alpha-diol:BSA or 3 alpha-diol&BSA facilitated receptivity within 90 min. Other estradiol-treated rats received steroid implants in the preoptic area (POA); those receiving P:BSA or P&BSA showed significant elevations in lordosis in 5 min. When systemic P was given, 3 alpha-diol:BSA and 3 alpha-diol&BSA applied to the MBH or POA inhibited receptivity. When 3 alpha-diol was given systemically, 3 alpha-diol:BSA implants to the MBH and POA produced facilitatory effects. These data suggest 3 alpha-diol can act at the membrane and that these effects are influenced by circulating steroids; yet membrane-mediated actions do not account for all of P-facilitated sexual behavior in the MBH and POA.

摘要

在内侧基底下丘脑（MBH）植入套管的去卵巢大鼠接受了与牛血清白蛋白（BSA）偶联的3α-二醇（3α-二醇：BSA）、用BSA稀释的游离3α-二醇（3α-二醇&BSA）、与BSA偶联的孕酮（P）（P：BSA）、用BSA稀释的游离P（P&BSA）或单独的BSA植入物。3α-二醇：BSA或3α-二醇&BSA在90分钟内促进了接受性。其他经雌二醇处理的大鼠在视前区（POA）接受类固醇植入物；接受P：BSA或P&BSA的大鼠在5分钟内出现显著的脊柱前凸升高。当给予全身P时，应用于MBH或POA的3α-二醇：BSA和3α-二醇&BSA抑制了接受性。当全身给予3α-二醇时，植入到MBH和POA的3α-二醇：BSA产生促进作用。这些数据表明3α-二醇可以作用于细胞膜，并且这些作用受循环类固醇的影响；然而，膜介导的作用并不能解释MBH和POA中所有P促进的性行为。

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