Murphy P G, Ogilvy A J, Whiteley S M
Department of Anaesthesia, General Infirmary at Leeds, UK.
Eur J Anaesthesiol. 1996 Sep;13(5):471-3. doi: 10.1046/j.1365-2346.1996.00003.x.
We have examined the effect of propofol on the neutrophil respiratory burst. Chemiluminescence was used as a measure of the respiratory burst following stimulation with 10(-5) M N-formyl-L-methionyl-L-leucyl-L-phenylalanine. Propofol 1.25, 2.5 and 5.0 x 10(-5) M inhibited neutrophil chemiluminescence by 29.6, 43.0 and 57.6%, respectively, in neutrophils prepared from healthy adult volunteers, and by 25.5, 37.4 and 54.7% in cells from patients with severe sepsis. We conclude that propofol interferes with the ability of human neutrophils to generate reactive oxygen species.
我们研究了丙泊酚对中性粒细胞呼吸爆发的影响。采用化学发光法测定用10(-5)M N-甲酰-L-蛋氨酰-L-亮氨酰-L-苯丙氨酸刺激后的呼吸爆发。在从健康成年志愿者制备的中性粒细胞中，1.25、2.5和5.0×10(-5)M丙泊酚分别使中性粒细胞化学发光抑制29.6%、43.0%和57.6%；在严重脓毒症患者的细胞中，分别抑制25.5%、37.4%和54.7%。我们得出结论，丙泊酚会干扰人类中性粒细胞产生活性氧的能力。
