Doshi J C, Vaidya A B, Sen H G, Mankodi N A, Nair C N, Grewal R S
Am J Trop Med Hyg. 1977 Jul;26(4):636-9. doi: 10.4269/ajtmh.1977.26.636.
A new compound, 4-isothiocyanato-4'-nitrodiphenylamine (C.9333-Go/CGP 4540), was tried in 39 hospitalized patients with hookworm infection, using several treatment schedules. At effective dose schedules (125 mg X 3 given 4-hourly; 250 mg X 3, 8-hourly; 1,000 mg X 3, 12-hourly), the egg reduction was 96% to 100%; the zero egg-counts were confirmed by coproculture for larvae. The compound was very well tolerated. Transient and mild side effects--giddiness, diarrhea and sweating--were observed in only three patients. No toxic effects were seen as judged by serial organ function tests, except a transient and mild asymptomatic elevation of transaminases in one patient.
一种新化合物，4-异硫氰酸基-4'-硝基二苯胺（C.9333-Go/CGP 4540），采用几种治疗方案，在39例住院钩虫感染患者中进行了试验。在有效剂量方案下（每4小时给予125毫克×3次；每8小时给予250毫克×3次；每12小时给予1000毫克×3次），虫卵减少率为96%至100%；通过幼虫粪便培养证实虫卵计数为零。该化合物耐受性良好。仅3例患者出现短暂且轻微的副作用——头晕、腹泻和出汗。除1例患者转氨酶出现短暂且轻微的无症状升高外，连续器官功能测试未发现有毒作用。
