Nwokolo C, Volkmer K J
Am J Trop Med Hyg. 1977 Jul;26(4):688-92. doi: 10.4269/ajtmh.1977.26.688.
Menichlopholan, biphenyl compound, in a single dose of 2 mg/kg body weight, gave a 73%-90% cure rate in the treatment of pulmonary infections due to Paragonimus uterobilateralis at two centers in Nigeria. Ninety-five patients were followed up for 4 months, and 58 for 1 year. Side effects of the drug included sweating and body pains, but there was no significnat biochemical or hematological evidence of damage to the internal organs. The advantages of single dose therapy are likely to make menichlopholan the treatment of choice for paragonimiasis in Africa, and probably elsewhere.
在尼日利亚的两个医疗中心，使用联苯化合物氯酚磷胺单剂量按2毫克/千克体重给药，治疗双侧子宫并殖吸虫引起的肺部感染，治愈率达73%至90%。95名患者接受了4个月的随访，58名患者接受了1年的随访。该药物的副作用包括出汗和身体疼痛，但没有显著的生化或血液学证据表明对内脏器官造成损害。单剂量疗法的优势可能会使氯酚磷胺成为非洲及其他地区并殖吸虫病的首选治疗药物。
