Gray G C, Coate B D, Anderson C M, Kang H K, Berg S W, Wignall F S, Knoke J D, Barrett-Connor E
Clinical Epidemiology Division, Naval Health Research Center, San Diego, CA 92186-5122, USA.
N Engl J Med. 1996 Nov 14;335(20):1505-13. doi: 10.1056/NEJM199611143352007.
Since the Persian Gulf War ended in 1991, many veterans of that conflict have reported diverse, unexplained symptoms. To evaluate the health of Gulf War veterans, we studied their postwar hospitalization experience and compared it with that of other military personnel serving at the same time who did not go to the Persian Gulf.
Using a retrospective cohort approach and data from Department of Defense hospitals, we studied hospitalizations of 547,076 veterans of the Gulf War who were serving in the Army, Navy, Marine Corps, and Air Force and 618,335 other veterans from the same era who did not serve in the Persian Gulf. Using multivariate logistic-regression models, we analyzed risk factors for hospitalization both overall and in 14 broad diagnostic categories during three periods from August 1991 through September 1993 (a total of 45 specific comparisons).
After the war, the overall odds ratio for hospitalization of the Gulf War veterans was not higher than that of the other veterans, even after adjustment for selection effects related to deployment. In 16 of the 42 comparisons involving specific diagnoses, the risk of hospitalization among Gulf War veterans differed significantly from that among other veterans. Among these 16 comparisons, Gulf War veterans were at higher risk in 5: neoplasms (largely benign) during 1991, diseases of the genitourinary system during 1991, diseases of the blood and blood-forming organs (mostly forms of anemia) during 1992, and mental disorders during both 1992 and 1993. The differences were not consistent over time and could be accounted for by deferred care, postwar pregnancies, and postwar stress.
During the two years after the Persian Gulf War, there was no excess of unexplained hospitalization among Americans who remained on active duty after serving in that conflict.
自1991年海湾战争结束以来,许多参加过那场冲突的退伍军人报告了各种不明原因的症状。为评估海湾战争退伍军人的健康状况,我们研究了他们战后的住院经历,并将其与同时期未前往波斯湾的其他军事人员的住院经历进行了比较。
我们采用回顾性队列研究方法,利用国防部医院的数据,研究了陆军、海军、海军陆战队和空军中547,076名海湾战争退伍军人以及同一时期未在波斯湾服役的618,335名其他退伍军人的住院情况。使用多变量逻辑回归模型,我们分析了1991年8月至1993年9月这三个时期总体以及14个广泛诊断类别的住院风险因素(共45项具体比较)。
战后,即使在对与部署相关的选择效应进行调整后,海湾战争退伍军人的总体住院比值比也不高于其他退伍军人。在涉及特定诊断的42项比较中,有16项显示海湾战争退伍军人的住院风险与其他退伍军人存在显著差异。在这16项比较中,海湾战争退伍军人在5项中风险较高:1991年的肿瘤(大多为良性)、1991年的泌尿生殖系统疾病、1992年的血液及造血器官疾病(大多为贫血形式)以及1992年和1993年的精神障碍。这些差异在不同时间并不一致,可能是由于延迟治疗、战后怀孕和战后压力所致。
在海湾战争后的两年里,在那场冲突中服役后仍在现役的美国人中,未出现不明原因住院人数过多的情况。