Cowan D N, DeFraites R F, Gray G C, Goldenbaum M B, Wishik S M
Walter Reed Army Institute of Research, Washington, D.C., USA.
N Engl J Med. 1997 Jun 5;336(23):1650-6. doi: 10.1056/NEJM199706053362306.
There has been suspicion that service in the Persian Gulf War affected the health of veterans adversely, and there have been claims of an increased rate of birth defects among the children of those veterans.
We evaluated the routinely collected data on all live births at 135 military hospitals in 1991, 1992, and 1993. The data base included up to eight diagnoses from the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) for each birth hospitalization, plus information on the demographic characteristics and service history of the parents. The records of over 75,000 newborns were evaluated for any birth defect (ICD-9-CM codes 740 to 759, plus neoplasms and hereditary diseases) and for birth defects defined as severe on the basis of the specific diagnoses and the criteria of the Centers for Disease Control and Prevention.
During the study period, 33,998 infants were born to Gulf War veterans and 41,463 to non-deployed veterans at military hospitals. The overall risk of any birth defect was 7.45 percent, and the risk of severe birth defects was 1.85 percent. These rates are similar to those reported in civilian populations. In the multivariate analysis, there was no significant association for either men or women between service in the Gulf War and the risk of any birth defect or of severe birth defects in their children.
This analysis finds no evidence of an increase in the risk of birth defects among the children of Gulf War veterans.
一直有人怀疑海湾战争服役经历对退伍军人的健康产生了不利影响，并且有说法称这些退伍军人的子女出生缺陷率有所上升。
我们评估了1991年、1992年和1993年135家军队医院所有活产儿的常规收集数据。数据库包括每次出生住院时根据《国际疾病分类》第九版临床修订本（ICD - 9 - CM）最多八项诊断，以及父母的人口统计学特征和服役史信息。对超过75,000名新生儿的记录进行评估，以确定是否存在任何出生缺陷（ICD - 9 - CM编码740至759，加上肿瘤和遗传性疾病），并根据具体诊断和疾病控制与预防中心的标准确定是否为严重出生缺陷。
在研究期间，军队医院中有33,998名婴儿为海湾战争退伍军人所生，41,463名婴儿为未部署的退伍军人所生。任何出生缺陷的总体风险为7.45%，严重出生缺陷的风险为1.85%。这些比率与平民人口中报告的比率相似。在多变量分析中，海湾战争服役经历与男性或女性子女出现任何出生缺陷或严重出生缺陷的风险之间均无显著关联。
该分析未发现海湾战争退伍军人子女出生缺陷风险增加的证据。
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