Muto Y
Department of Hematology, Toranomon Hospital.
Nihon Rinsho. 1996 Sep;54(9):2402-6.
Hemolysis is characterized by shortening of the red cell life span. When the red cell destruction exceeds the ability of the marrow to increase red cell production to compensate for, hemolytic anemias develop. These conditions are subdivided into hereditary abnormalities and acquired abnormalities. Except for PNH, all types of hemolytic anemia due to intrinsic abnormalities are inherited and those of extrinsic ones are acquired. Extrinsic factors include antibodies, physical trauma, biological agents, chemical agents and physical agents. For determining the specific cause of the conditions, anti-globulin test, morphological observation, analysis of hemoglobin, red cell enzyme assay, screening tests for PNH are needed.
溶血的特征是红细胞寿命缩短。当红细胞破坏超过骨髓增加红细胞生成以进行补偿的能力时，就会发生溶血性贫血。这些情况可细分为遗传性异常和获得性异常。除阵发性睡眠性血红蛋白尿症（PNH）外，所有由内在异常引起的溶血性贫血类型都是遗传性的，而由外在异常引起的则是获得性的。外在因素包括抗体、物理创伤、生物制剂、化学制剂和物理因素。为了确定这些病症的具体病因，需要进行抗球蛋白试验、形态学观察、血红蛋白分析、红细胞酶测定、PNH筛查试验。
