环磷酸腺苷调节小鼠胎盘和蜕膜中激活素和抑制素亚基mRNA的表达：一篇简短通讯

Cyclic AMP regulates expression of activin and inhibin subunit mRNAs in the mouse placenta and decidua: a short communication.

作者信息

Yamaguchi M, Fujii M, Miyake A

机构信息

Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.

出版信息

Eur J Endocrinol. 1996 Sep;135(3):379-81. doi: 10.1530/eje.0.1350379.

DOI:10.1530/eje.0.1350379

PMID:8890732

Abstract

We examined whether cAMP regulates expression of activin/inhibin subunit mRNAs in the mouse placenta and decidua. 8-Bromo-cAMP inhibited expression of inhibin alpha-subunit mRNA but stimulated expression of activin/inhibin beta A- and beta B-subunit mRNAs in placenta and decidua by the 3rd day of culture. Forskolin and cholera toxin also regulated expression of activin/inhibin subunit mRNAs in the same manner. However, activin-A did not affect expression of activin/inhibin subunit mRNAs. These findings suggest that cAMP inhibits inhibin production but stimulates activin production in the mouse placenta and decidua.

摘要

我们研究了环磷酸腺苷（cAMP）是否调节小鼠胎盘和蜕膜中激活素/抑制素亚基mRNA的表达。在培养的第3天，8-溴环磷酸腺苷抑制了抑制素α亚基mRNA的表达，但刺激了胎盘和蜕膜中激活素/抑制素βA和βB亚基mRNA的表达。福斯高林和霍乱毒素也以同样的方式调节激活素/抑制素亚基mRNA的表达。然而，激活素-A并不影响激活素/抑制素亚基mRNA的表达。这些发现表明，cAMP在小鼠胎盘和蜕膜中抑制抑制素的产生，但刺激激活素的产生。