Rajapakse J C, Giedd J N, Rumsey J M, Vaituzis A C, Hamburger S D, Rapoport J L
Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1600, USA.
Brain Dev. 1996 Sep-Oct;18(5):379-88. doi: 10.1016/0387-7604(96)00034-4.
A technique for quantifying the midsagittal size and shape of the corpus callosum (CC) from magnetic resonance brain scans is presented. The technique utilizes the distances to the ventral and dorsal boundaries of small sectors of the CC from a reference point to compute the size and shape parameters of the CC and its subdivisions. Intrarater and interrater interclass correlation coefficients for the area measurements ranged from 0.88 to 0.99. Correlations between these automated measures and those obtained by pixel counting were equally high. The corpus callosa of 104 (57 male and 47 female) right-handed healthy children and adolescents, ages 4-18, were examined in relation to age and sex. Corpus callosum growth was most striking for the splenium and isthmus with some changes in the midbody regions. The area and perimeter of these regions increased, shapes became more compact, and the boundaries became more regular with age. The length and curvature at the anterior and posterior regions of the CC increased more rapidly in males than in females. These significant and consistent results indicate that the method is reliable and sensitive to developmental changes of the CC.
本文介绍了一种从脑部磁共振扫描中量化胼胝体（CC）矢状面中部大小和形状的技术。该技术利用从参考点到CC小扇形区域腹侧和背侧边界的距离来计算CC及其各亚区的大小和形状参数。面积测量的组内和组间类内相关系数在0.88至0.99之间。这些自动测量值与通过像素计数获得的值之间的相关性同样很高。对104名（57名男性和47名女性）4至18岁右利手健康儿童和青少年的胼胝体进行了年龄和性别的相关性研究。胼胝体的压部和峡部生长最为显著，中部区域也有一些变化。随着年龄增长，这些区域的面积和周长增加，形状变得更加紧凑，边界变得更加规则。CC前后区域的长度和曲率在男性中比在女性中增加得更快。这些显著且一致的结果表明该方法对CC的发育变化可靠且敏感。
