Jäncke L, Preis S, Steinmetz H
Institute for General Psychology, Otto-von-Guericke-University Magdeburg, Germany.
Neuroreport. 1999 Sep 29;10(14):2981-5. doi: 10.1097/00001756-199909290-00020.
Applying in vivo magnetic resonance (MR) morphometry in healthy adults we have recently discovered that the relationship between forebrain volume (FBV) and the midsagittal size of the corpus callosum (CC) follows a geometrical rule according to which larger brains have a relatively smaller midsagittal CC. This allometric relation was taken as support for the hypotheses of Ringo and co-workers suggesting that brain size may be an important factor influencing interhemispheric connectivity and lateralization. In this paper we examined whether the aforementioned relation between FBV and CC size also holds for healthy children between 3 and 14 years of age. We confirmed this relationship as previously found for adults. Thus, the geometrical rule and the implications associated with it apply for a wide age range. In addition we found significant correlations with age for posterior and mid-parts of the CC even when FBV was controlled for, suggesting an anterior to posterior maturation gradient of CC development.
我们最近在健康成年人中应用活体磁共振（MR）形态测量法发现，前脑体积（FBV）与胼胝体（CC）矢状中部大小之间的关系遵循一种几何规则，即较大的大脑胼胝体矢状中部相对较小。这种异速生长关系被视为对林戈及其同事假说的支持，该假说认为脑容量可能是影响半球间连接和功能侧化的一个重要因素。在本文中，我们研究了上述FBV与CC大小之间的关系是否也适用于3至14岁的健康儿童。我们证实了这种关系与之前在成年人中发现的一致。因此，这种几何规则及其相关影响适用于很广的年龄范围。此外，即使在控制了FBV的情况下，我们发现CC后部和中部与年龄也存在显著相关性，这表明CC发育存在从前到后的成熟梯度。
